Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis
These preliminary findings suggest that anxiety PRS may help predict response to OSU6162 treatment in AD. Further research with larger cohorts and more comprehensive genetic data is needed to confirm these results and advance personalized medicine approaches for alcohol use disorder.
Authors
- Philippe A. Melas (ORCID: https://orcid.org/0000-0002-7889-9250)
- Lotfi Khemiri (ORCID: https://orcid.org/0000-0001-9510-7449)
- Johan Franck (ORCID: https://orcid.org/0000-0002-4355-1967)
- Nitya Jayaram‐Lindström (ORCID: https://orcid.org/0000-0002-2678-3782)
- Joar Guterstam (ORCID: https://orcid.org/0000-0002-2643-4291)
- Mun‐Gwan Hong
Institutions
- Karolinska University Hospital (SE)
- Stockholm University (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
- Stockholm Health Care Services (SE)
Publication Details
- Journal
- Pharmacological Reports
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1007/s43440-025-00707-8
- Primary Topic
- Substance Abuse Treatment and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Office of Research and Development
- Karolinska Institutet