Single‐Benzene‐Based Clickable Fluorophores for In Vitro and In Vivo Bioimaging
A series of miniaturized, clickable single-benzene-based fluorophores derived from tetrafluoroterephthalonitrile is reported. Fluorophores based on a tetrahydroquinoxaline skeleton exhibited improved photophysical properties due to enhanced electron delocalization between donor and acceptor groups compared to those with a dihydro[1,4]thiazine skeleton. These easily synthesized clickable fluorophores were successfully applied in both in vitro and in vivo bioimaging following protein conjugation.
Authors
- Andrejus Suchenko (ORCID: https://orcid.org/0000-0002-4832-1642)
- Martin Wills (ORCID: https://orcid.org/0000-0002-1646-2379)
- Michael Shipman (ORCID: https://orcid.org/0000-0002-3349-5594)
- Mohan K. Balasubramanian (ORCID: https://orcid.org/0000-0002-1292-8602)
- Guy J. Clarkson (ORCID: https://orcid.org/0000-0003-3076-3191)
- Stefan Roesner (ORCID: https://orcid.org/0000-0003-2143-4708)
- Raja Mohanrao
- Clyde S. Pinto (ORCID: https://orcid.org/0009-0002-7827-9139)
Institutions
- Durham University (GB)
- University of Warwick (GB)
- Liverpool John Moores University (GB)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1002/slct.202405738
- Citations
- 2
- Primary Topic
- Luminescence and Fluorescent Materials
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- Wellcome Trust
- University of Warwick