Clinical heterogeneity and treatment outcomes of extrapulmonary tuberculosis in a low-incidence setting: insights from a prospective cohort study
EPTB exhibits highly variable disease severity and organ involvement. Treatment initiation is often delayed due to diagnostic challenges. Management is complicated by the frequent occurrence of PR, which can lead to treatment durations exceeding standard recommendations. Clinical scores for treatment response assessment may not be reliably applicable, highlighting the need for alternative biomarkers.
Authors
- Samuel Rohr
- Margarete Scherer (ORCID: https://orcid.org/0000-0002-6938-6373)
- Philipp Schommers (ORCID: https://orcid.org/0000-0003-3375-6800)
- A Hoffmann (ORCID: https://orcid.org/0000-0002-3093-8417)
- Jakob J Malin (ORCID: https://orcid.org/0000-0002-2989-0436)
- Jan Rybniker (ORCID: https://orcid.org/0000-0001-8351-2690)
- Lena M. Biehl (ORCID: https://orcid.org/0000-0001-7613-8119)
- Jörg Janne Vehreschild (ORCID: https://orcid.org/0000-0002-5446-7170)
- Alexander Simonis (ORCID: https://orcid.org/0000-0003-2945-9897)
- Marie Feldmann
- Lena Junker
- Angela Klingmüller
- Gerd Fätkenheuer (ORCID: https://orcid.org/0000-0002-5054-1871)
- Clara Lehmann (ORCID: https://orcid.org/0000-0002-7042-1578)
- Natalie Funke
- Dominic Rauschning (ORCID: https://orcid.org/0000-0001-9284-8778)
- Jonathan Jantsch (ORCID: https://orcid.org/0000-0001-6944-2913)
- Isabelle Suárez
- Kirsten Schmidt-Hellerau (ORCID: https://orcid.org/0000-0003-4426-9565)
- Víctor Suárez (ORCID: https://orcid.org/0000-0002-7078-4731)
- Lea Helmhold
Institutions
- Goethe University Frankfurt (DE)
- University of Cologne (DE)
- German Center for Infection Research (DE)
- Evangelisches Krankenhaus Düsseldorf (DE)
- University Hospital Cologne (DE)
- Bundeswehrzentralkrankenhaus Koblenz (DE)
Publication Details
- Journal
- Infection
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1007/s15010-025-02500-4
- Citations
- 10
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 13.96
Funders
- Universität zu Köln
- Universitätsklinikum Köln