Cu(OAc)<sub>2</sub>.H<sub>2</sub>O used as acetoxy source for the selective C(sp<sup>2</sup>)‐H acetoxylation: Synthesis of Acetoxylated Indoles/bisindolyl
Abstract For the first time, Cu(OAc) 2 .H 2 O has been demonstrated as an effective source of acetoxy groups for the selective oxidative acetoxylation of Csp 2 ‐H bonds. We present a method that selectively acetoxylation of indoles and bisindolyls with high regioselectivity, thus allowing us to specifically functionalize specific molecule positions while leaving other reactive sites unaffected. The Cu(OAc) 2 .H 2 O mediated acetoxylation method has milder reaction conditions and a greater compatibility between functional groups, allowing for the efficient synthesis of complex indoles and bisindolyl derivatives. Similar efficiency was observed on gram scales.
Authors
- Peramalla Edukondalu
- Sabbasani Rajasekhara Reddy (ORCID: https://orcid.org/0000-0002-3813-7235)
- Praveen Kumar Naikawadi
Institutions
- Central University of Kerala (IN)
- Vellore Institute of Technology University (IN)
- Osmania University (IN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1002/ajoc.202400763
- Primary Topic
- Chemical Synthesis and Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00