Combining Top‐Down and Bottom‐Up: An Open Microfluidic Microtumor Model for Investigating Tumor Cell‐ECM Interaction and Anti‐Metastasis (Small 9/2025)

Microtumor Model By leveraging an exclusive liquid repellency (ELR)-underoil open microfluidic system (UOMS), an open microfluidics-based microtumor model for studying tumor cell migration in an in vivo-like confined space and interaction with extracellular matrix was developed. The UOMS microtumor model was tested with the anti-metastatic effect of incyclinide, showing the potential as an ex vivo platform for micrometastasis study and anti-metastasis drug screening. More in article number 2402499, Chao Li, Yingguang Liu, and co-workers.