Adipose stromal cells increase insulin sensitivity and decrease liver gluconeogenesis in a mouse model of type 1 diabetes mellitus
Together, these findings suggest that adipose tissue-derived SVF cells could suppress liver inflammation, regulate liver gluconeogenesis, and improve insulin sensitivity in an animal model with T1D. Therefore, adipose SVF cells may be novel cellular therapeutic alternatives to maintain steady liver gluconeogenesis in T1D.
Authors
- Lee-Wei Chen (ORCID: https://orcid.org/0000-0002-3583-1248)
- Yen-Ju Lee
- Pei-Hsuan Chen
- Chia-Hua Tang
- Hsiao-Chi Lai (ORCID: https://orcid.org/0000-0002-8332-8970)
Institutions
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Zuoying Armed Forces General Hospital (TW)
- Kaohsiung Veterans General Hospital (TW)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13287-025-04225-5
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00