High susceptibility to the novel antimicrobial zoliflodacin among Neisseria gonorrhoeae isolates in eight WHO Enhanced Gonococcal Antimicrobial Surveillance Programme countries in three WHO regions, 2021-2024
We show a high susceptibility to zoliflodacin internationally, including against ceftriaxone- and azithromycin-resistant gonococcal strains. Our findings support the continued clinical development of zoliflodacin as a treatment for gonorrhea, although cautious and monitored introduction and continuous international resistance surveillance are imperative.
Authors
- Teodora Wi (ORCID: https://orcid.org/0000-0002-7640-9166)
- Manuel C Jamoralin
- Vichea Ouk (ORCID: https://orcid.org/0009-0006-5659-8402)
- Ismaël Maatouk (ORCID: https://orcid.org/0000-0003-1008-7413)
- Peter Kyambadde (ORCID: https://orcid.org/0000-0002-9606-218X)
- Thuy Thi Phan Nguyen
- E Müller (ORCID: https://orcid.org/0000-0002-9800-491X)
- Daniel Golparian (ORCID: https://orcid.org/0000-0002-0688-2521)
- Francis Kakooza (ORCID: https://orcid.org/0000-0003-4047-6620)
- Sonia Sia (ORCID: https://orcid.org/0009-0005-2475-9577)
- Phạm Thị Làn (ORCID: https://orcid.org/0000-0002-0127-9328)
- Magnus Unemo (ORCID: https://orcid.org/0000-0003-1710-2081)
- Nguyễn Thị Thuỳ Vân (ORCID: https://orcid.org/0000-0002-6526-0175)
- Rossaphorn Kittiyaowamarn (ORCID: https://orcid.org/0000-0001-9382-7776)
- Mitch Matoga (ORCID: https://orcid.org/0000-0002-6542-8193)
- Thitima Cherdtrakulkiat (ORCID: https://orcid.org/0000-0001-5006-6145)
- Vivi Setiawaty (ORCID: https://orcid.org/0000-0002-1196-7909)
- Mot Virak
- Heng Li (ORCID: https://orcid.org/0000-0002-6666-0277)
- Irving Hoffman (ORCID: https://orcid.org/0000-0003-0059-5991)
- Dumisile V. Maseko (ORCID: https://orcid.org/0000-0002-9707-9485)
- Susanne Jacobsson
- Daniel Schröder
- Verawati Sulaiman
Institutions
- National Health Laboratory Service (ZA)
- Department of Health (PH)
- Ministry of Public Health (TH)
- Örebro University (SE)
- Research Institute for Tropical Medicine (PH)
- Ministry of Health (UG)
- National Institute of Public Health (KH)
- World Health Organization (CH)
- National Center for HIV/AIDS, Dermatology and STD (KH)
- HCMC Hospital of Dermato Venereology (VN)
- Infectious Diseases Institute (UG)
- Hanoi Medical University Hospital (VN)
- University College London (GB)
- Makerere University (UG)
Publication Details
- Journal
- IJID Regions
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.ijregi.2025.100624
- Citations
- 3
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 3.55