Single-cell transcriptomics analysis reveals that the tumor-infiltrating B cells determine the indolent fate of papillary thyroid carcinoma
This study provides insights into the cellular landscape of early-stage PTC, revealing distinct tumor and immune microenvironment features in indolent and progressive cases. These findings advance the understanding of indolent PTC biology and support the development of reliable diagnostic and prognostic biomarkers.
Authors
- Shuyan Zhao
- Zhizhong Dong (ORCID: https://orcid.org/0000-0002-4493-322X)
- Ruochuan Cheng (ORCID: https://orcid.org/0000-0003-1292-4780)
- Weihan Cao
- Yanjun Su (ORCID: https://orcid.org/0000-0001-7931-339X)
- Wen Liu (ORCID: https://orcid.org/0000-0002-8415-2161)
- Chunmei Li (ORCID: https://orcid.org/0000-0002-8619-1842)
- Jianming Zhang (ORCID: https://orcid.org/0009-0000-1113-7860)
- Zhiyuan Wang (ORCID: https://orcid.org/0000-0002-5285-3596)
- Li Shi (ORCID: https://orcid.org/0000-0001-9120-2510)
- Pei Wang (ORCID: https://orcid.org/0000-0002-0538-7641)
- Zi Lei
Institutions
- Yunnan University (CN)
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13046-025-03341-7
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11