REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness
LC activity during wakefulness was related to REM sleep intensity and to a transient EEG change preceding REM sleep, a feature causally related to LC activity in animal studies. The associations depend on the cognitive task, suggesting that a balanced level of LC tonic activity during wakefulness is required for optimal expression of REM sleep. The findings may have implications for the high prevalence of sleep complaints reported in aging and for disorders such as insomnia, Alzheimer's, and Parkinson's disease, for which the LC may play pivotal roles through sleep.
Authors
- Mikhail Zubkov
- Gilles Vandewalle (ORCID: https://orcid.org/0000-0003-2483-2752)
- Christophe Phillips (ORCID: https://orcid.org/0000-0002-4990-425X)
- Christine Bastin (ORCID: https://orcid.org/0000-0002-4556-9490)
- Pierre Maquet
- Ilenia Paparella (ORCID: https://orcid.org/0000-0002-7683-2503)
- Roya Sharifpour (ORCID: https://orcid.org/0000-0002-3164-0735)
- Laurent Lamalle (ORCID: https://orcid.org/0000-0002-8930-7337)
- Fabienne Collette (ORCID: https://orcid.org/0000-0001-9288-9756)
- Nasrin Mortazavi
- Alexandre Berger (ORCID: https://orcid.org/0000-0002-1739-9623)
- Christian Berthomier (ORCID: https://orcid.org/0000-0002-2300-9476)
- Ekaterina Koshmanova (ORCID: https://orcid.org/0000-0002-0191-2808)
- Elise Beckers (ORCID: https://orcid.org/0000-0002-5523-1741)
- Fermin Balda (ORCID: https://orcid.org/0000-0002-0943-8928)
- Puneet Talwar (ORCID: https://orcid.org/0000-0001-7631-7926)
- Islay Campbell (ORCID: https://orcid.org/0000-0003-4497-6673)
- Ismael Dardour Hamzaoui
Institutions
- University of Liège (BE)
- Maastricht University (NL)
- Centre Hospitalier Universitaire de Liège (BE)
- Collège de Physique et de Philosophie (FR)
- UCLouvain (BE)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s12929-025-01127-9
- Citations
- 4
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 5.72
Funders
- Fédération Wallonie-Bruxelles
- Université de Liège
- Fonds Léon Fredericq
- Fondation pour la Recherche sur Alzheimer
- Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture
- European Regional Development Fund
- H2020 Marie Skłodowska-Curie Actions