Ursolic Acid‐Bonded Magnetic Nanoparticles Catalyzed the One‐Pot Synthesis of New Hexahydroquinoline‐3‐carboxamides

Abstract In this research, we present an effective method for synthesizing new derivatives of hexahydroquinoline‐3‐carboxamides through a one‐pot synthesis using formylarylsulfonates, dimedone or 1,3‐cyclohexanedione, acetoacetanilide, and ammonium acetate in high to excellent yield in EtOH at reflux conditions. This method utilizes ursolic acid (UA)‐bonded magnetic nanoparticles (nano‐Fe 3 O 4 @UA) as a catalyst. The method offers several advantages, including high yield, short reaction time, and simplicity, making it an attractive and efficient option in the emerging field of hexahydroquinolines synthesis.

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Publication Details

Journal
ChemistrySelect
Published
2025-03-01
DOI
https://doi.org/10.1002/slct.202405798
Citations
1
Primary Topic
Multicomponent Synthesis of Heterocycles
Type
article
Field-Weighted Citation Impact
0.94
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article

Ursolic Acid‐Bonded Magnetic Nanoparticles Catalyzed the One‐Pot Synthesis of New Hexahydroquinoline‐3‐carboxamides

Fatemeh Azmian Moghadam, Masoud Mokhtary, Leila Asadpour, Tahereh Moradhosseini
1 citations
ChemistrySelect
Multicomponent Synthesis of Heterocycles
0.94
article

Ursolic Acid‐Bonded Magnetic Nanoparticles Catalyzed the One‐Pot Synthesis of New Hexahydroquinoline‐3‐carboxamides

Fatemeh Azmian Moghadam, Masoud Mokhtary, Leila Asadpour, Tahereh Moradhosseini
article en
1 citations

Abstract

Abstract In this research, we present an effective method for synthesizing new derivatives of hexahydroquinoline‐3‐carboxamides through a one‐pot synthesis using formylarylsulfonates, dimedone or 1,3‐cyclohexanedione, acetoacetanilide, and ammonium acetate in high to excellent yield in EtOH at reflux conditions. This method utilizes ursolic acid (UA)‐bonded magnetic nanoparticles (nano‐Fe 3 O 4 @UA) as a catalyst. The method offers several advantages, including high yield, short reaction time, and simplicity, making it an attractive and efficient option in the emerging field of hexahydroquinolines synthesis.

ChemistrySelectVol. 10(10)
Guilan University of Medical Sciences (IR), Islamic Azad University Rasht Branch (IR)
Openalex Percentile: Top 28%
Multicomponent Synthesis of Heterocycles
0.94
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