Selective Enhancer Dependencies in <i>MYC</i> -Intact and <i>MYC</i> -Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma
Aberrant MYC activity defines the most aggressive GCB-DLBCLs. We characterized a mechanism of MYC transcriptional activation via a native enhancer that is active in MYC-intact GCB-DLBCL, establishing fitness-sustaining cis- and trans-regulatory circuitry in GCB-DLBCL models that lack MYC enhancer-hijacking rearrangement. See related commentary by Mulet-Lazaro and Delwel, p. 149.
Authors
- Cody N. Hall (ORCID: https://orcid.org/0000-0002-4601-4649)
- Athalee R. Aguilar (ORCID: https://orcid.org/0000-0002-3522-2039)
- Ashwin Iyer (ORCID: https://orcid.org/0000-0001-9846-8442)
- Abdullah Ramzan (ORCID: https://orcid.org/0009-0001-5776-316X)
- Kristin Sikkink (ORCID: https://orcid.org/0000-0002-0805-0622)
- Anamarija M. Perry (ORCID: https://orcid.org/0000-0002-5700-2141)
- Matthew B. Weiss (ORCID: https://orcid.org/0000-0001-6127-7626)
- Aishwarya Gurumurthy (ORCID: https://orcid.org/0000-0003-0779-1434)
- Anthony D. Schmitt (ORCID: https://orcid.org/0000-0002-3818-1156)
- Marcin Cieślik (ORCID: https://orcid.org/0000-0002-5467-1040)
- Charles P. Fulco (ORCID: https://orcid.org/0000-0002-6592-1279)
- Anna B. Owczarczyk (ORCID: https://orcid.org/0000-0001-9871-456X)
- Rockwell Anyoha (ORCID: https://orcid.org/0000-0002-0363-3095)
- Juhi Gupta (ORCID: https://orcid.org/0000-0003-4518-4221)
- John S. Runge (ORCID: https://orcid.org/0000-0001-6489-8575)
- Travis Saari (ORCID: https://orcid.org/0000-0001-8561-8317)
- Noah A. Brown (ORCID: https://orcid.org/0000-0001-9151-5912)
- Rohan Kodgule (ORCID: https://orcid.org/0000-0002-1711-8641)
- Russell J.H. Ryan (ORCID: https://orcid.org/0000-0001-8174-3962)
- Alec Chu (ORCID: https://orcid.org/0000-0003-3337-7421)
- Jan Rosa
- J Engreitz (ORCID: https://orcid.org/0000-0002-5754-1719)
- Jang Hwan Cho
- Arvind Emmanuel
- Savanna Gemus
Institutions
- Broad Institute (US)
- Cleveland Clinic (US)
- Lucile Packard Children's Hospital (US)
- University of Michigan (US)
- Harvard University Press (US)
- University of Chicago (US)
- Arima Genomics (United States) (US)
- Michigan United (US)
- ID Genomics (United States) (US)
- Massachusetts Institute of Technology (US)
- Stanford University (US)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1158/2643-3230.bcd-24-0126
- Citations
- 5
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.36