Enhanced mitochondrial function and delivery from adipose-derived stem cell spheres via the EZH2-H3K27me3-PPARγ pathway for advanced therapy
Enhancing mitochondrial ATP production via the EZH2-H3K27me3-PPARγ pathway offers an alternative strategy to conventional cell-based therapies. High-functional mitochondria and delivery efficiency show significant potential for regenerative medicine applications.
Authors
- Huệ Thị Vũ
- Dinh‐Toi Chu (ORCID: https://orcid.org/0000-0002-4596-2022)
- Thamil Selvee Ramasamy (ORCID: https://orcid.org/0000-0003-1720-3907)
- Shau‐Ping Lin (ORCID: https://orcid.org/0000-0003-3423-991X)
- Ming‐Min Chang (ORCID: https://orcid.org/0000-0002-6537-2249)
- Thuy Vu (ORCID: https://orcid.org/0000-0003-1056-6975)
- Jung‐Shun Lee (ORCID: https://orcid.org/0000-0003-4268-2161)
- Chia‐Ching Wu (ORCID: https://orcid.org/0000-0001-7224-8425)
- Sheng-Che Lin
Institutions
- National Taiwan University (TW)
- Vietnam National University, Hanoi (VN)
- China Medical University (TW)
- University of Malaya (MY)
- An-Nan Hospital (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13287-025-04164-1
- Citations
- 2
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Health Research Institutes