Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia
These findings suggest that childhood trauma may be associated with the onset of schizophrenia by influencing prolactin levels, highlighting the complex interplay between hormonal disruptions and early-life stress in the development of schizophrenia.
Authors
- Junyan Wu
- Yuqian Pan (ORCID: https://orcid.org/0009-0006-7756-5933)
- Jun Ma (ORCID: https://orcid.org/0000-0001-7836-8081)
- Jiamin Dai
- Leijun Li (ORCID: https://orcid.org/0000-0003-2411-3846)
- Ming Chen (ORCID: https://orcid.org/0009-0000-8839-2691)
- Qingni Shen (ORCID: https://orcid.org/0000-0002-0605-6043)
- Yanxi Liu (ORCID: https://orcid.org/0000-0002-2278-5844)
- Xiaowei Xia (ORCID: https://orcid.org/0000-0002-6700-7595)
- Ziyi Zhang (ORCID: https://orcid.org/0000-0001-9102-8292)
- Tong Liu (ORCID: https://orcid.org/0000-0001-9234-1328)
- Kexin Zhang (ORCID: https://orcid.org/0000-0002-9224-9465)
- Jihui Wang (ORCID: https://orcid.org/0000-0001-7586-8873)
- Zixin Deng (ORCID: https://orcid.org/0000-0003-0724-3390)
- Shimao Kang (ORCID: https://orcid.org/0009-0004-2819-1977)
- Qinling Wei
- Sichu Tao
- Zhinan Li (ORCID: https://orcid.org/0000-0002-4584-048X)
- Xiaobing Zou (ORCID: https://orcid.org/0000-0002-7380-0979)
Institutions
- Sun Yat-sen University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s12888-025-06629-2
- Citations
- 3
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Natural Science Foundation of China
- National Natural Science Foundation of China-Guangdong Joint Fund