Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia

These findings suggest that childhood trauma may be associated with the onset of schizophrenia by influencing prolactin levels, highlighting the complex interplay between hormonal disruptions and early-life stress in the development of schizophrenia.

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Publication Details

Journal
BMC Psychiatry
Published
2025-03-11
DOI
https://doi.org/10.1186/s12888-025-06629-2
Citations
3
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
4.41

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article

Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia

Junyan Wu, Yuqian Pan, Jun Ma, Jiamin Dai et al.
3 citations
BMC Psychiatry
Schizophrenia research and treatment
4.41
article

Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia

Junyan Wu, Yuqian Pan, Jun Ma, Jiamin Dai, Leijun Li, Ming Chen, Qingni Shen, Yanxi Liu, Xiaowei Xia, Ziyi Zhang, Tong Liu, Kexin Zhang, Jihui Wang, Zixin Deng, Shimao Kang, Qinling Wei, Sichu Tao, Zhinan Li, Xiaobing Zou
article en
3 citations

Abstract

These findings suggest that childhood trauma may be associated with the onset of schizophrenia by influencing prolactin levels, highlighting the complex interplay between hormonal disruptions and early-life stress in the development of schizophrenia.

BMC PsychiatryVol. 25(1)
Sun Yat-sen University (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Guangdong Academy of Medical Sciences (CN), Sun Yat-sen University Cancer Center (CN), Third Affiliated Hospital of Sun Yat-sen University (CN), Guangdong Provincial People's Hospital (CN), Southern Medical University (CN), Guangzhou Medical University (CN)
National Natural Science Foundation of China, National Natural Science Foundation of China-Guangdong Joint Fund
Good health and well-being
Openalex Percentile: Top 7%
Schizophrenia research and treatment
4.41
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