Integrated Single‐Cell Transcriptome and eQTL Analyses Reveal the Role of PZP in Aging and Chronic Kidney Disease
Shared genetic and immunological mechanisms link CKD and aging, with CD8+ T<sub>CM</sub> cells contributing to immune dysregulation and chronic inflammation. The dual role of PZP, involving its upregulation, disrupted immune communication, and metabolic reprogramming, highlights its potential as a biomarker and therapeutic target for aging-associated kidney diseases.
Authors
- Yulin Wang (ORCID: https://orcid.org/0000-0002-0890-5133)
- Cheng Zhu (ORCID: https://orcid.org/0000-0001-7472-4974)
- Shiqi Lv
- Yue Yang (ORCID: https://orcid.org/0000-0001-5530-9425)
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0002-0523-4581)
- Xiaoqiang Ding
- Songhua Yuan (ORCID: https://orcid.org/0000-0003-3351-5134)
- Jiayi Wang (ORCID: https://orcid.org/0009-0002-9109-0285)
- Xinhui Huang (ORCID: https://orcid.org/0009-0004-1494-0543)
Institutions
- Fudan University (CN)
- Shanghai Blood Center (CN)
- Zhongshan Hospital (CN)
- Shanghai Institute of Hematology (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- The Journal of Gene Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/jgm.70015
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- Shanghai Municipal Health Commission