Interobserver reproducibility of a hybrid three‐tier grading system of papillary nonmuscle invasive urothelial carcinoma: an international Uropathology study
Three-tier grading of papillary Ta NMIBC had substantial interobserver agreement amongst international uropathologists. The recognition of the HG-G3 case reached the highest concordance. North American uropathologists had comparable kappa scores (substantial agreement) to Europeans, despite being unaccustomed to separating HG cases into G2 and G3, demonstrating three-tier grading could be "quickly" adopted by genitourinary experts if endorsed and required by the relevant bodies in their jurisdiction of practice.
Authors
- Sean R. Williamson (ORCID: https://orcid.org/0000-0002-3898-1460)
- Sangeeta Desai (ORCID: https://orcid.org/0000-0002-3588-9888)
- Steven S. Shen (ORCID: https://orcid.org/0000-0001-7725-1260)
- Sebastian Mannweiler
- Maurits L. van Montfoort
- Sara E. Wobker (ORCID: https://orcid.org/0000-0001-5324-4197)
- Gladell P. Paner (ORCID: https://orcid.org/0000-0001-5839-6640)
- Hemamali Samaratunga (ORCID: https://orcid.org/0000-0001-5796-1791)
- Arndt Hartmann (ORCID: https://orcid.org/0000-0002-4860-4626)
- Theodorus van der Kwast (ORCID: https://orcid.org/0000-0001-8640-5786)
- Jon Oxley (ORCID: https://orcid.org/0000-0002-4348-0273)
- Katherine Lajkosz (ORCID: https://orcid.org/0000-0003-3760-5401)
- Joshua I. Warrick (ORCID: https://orcid.org/0000-0001-6149-1331)
- Ferrán Algaba
- Markus Eckstein (ORCID: https://orcid.org/0000-0001-5418-3349)
- Liang Cheng (ORCID: https://orcid.org/0000-0001-6049-5293)
- Mahul B. Amin (ORCID: https://orcid.org/0000-0001-5943-3634)
- Antonio López-Beltrán (ORCID: https://orcid.org/0000-0003-3161-8164)
- Michelle R. Downes (ORCID: https://orcid.org/0000-0002-4528-3724)
- Yves Allory (ORCID: https://orcid.org/0000-0002-4406-3316)
Institutions
- University of North Carolina at Chapel Hill (US)
- North Bristol NHS Trust (GB)
- Cleveland Clinic (US)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of Tennessee Health Science Center (US)
- The University of Queensland (AU)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Toronto (CA)
- Medical University of Graz (AT)
- Cornell University (US)
- Brown University (US)
- Tata Memorial Hospital (IN)
- Keck Hospital of USC (US)
- Health Sciences Centre (CA)
- Princess Margaret Cancer Centre (CA)
- The Netherlands Cancer Institute (NL)
- University of Chicago (US)
- Universitätsklinikum Erlangen (DE)
- Methodist Hospital (US)
- Puigvert Foundation (ES)
- Comprehensive Cancer Center Erlangen (DE)
- University of Córdoba (ES)
- Institut Curie (FR)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Histopathology
- Published
- 2025-03-09
- DOI
- https://doi.org/10.1111/his.15438
- Citations
- 5
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.03