<scp>CPCGI</scp> Alleviates Neural Damage by Modulating Microglial Pyroptosis After Traumatic Brain Injury
These findings suggest that CPCGI provides neuroprotection in TBI by targeting NLRP3 inflammasome-mediated microglial pyroptosis, thereby improving the neuroinflammatory microenvironment and promoting neurological recovery. This underscores its potential as a promising candidate for TBI treatment.
Authors
- Anchen Guo
- Tingting Yu (ORCID: https://orcid.org/0000-0002-1152-7137)
- Qun Wang (ORCID: https://orcid.org/0000-0002-5946-2918)
- Jian Wu (ORCID: https://orcid.org/0000-0002-3394-1507)
- Junmin Chen
- Lei Sun
- Li Yu
Institutions
- Capital Medical University (CN)
- Zhengzhou University (CN)
- Soochow University (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Chinese Institute for Brain Research (CN)
- Zhengzhou People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/cns.70322
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Beijing Municipal Natural Science Foundation
- National Key Research and Development Program of China