Radiation‐Enhanced <scp>AF1q</scp> Moves Center Stage as a Key Driver to Favorable Tumor Stage in Rectal Cancer Patients
AF1q is expressed in RC, especially after short-term radiation therapy. Here, AF1q may support tumor suppression, possibly through the involvement of the pro-apoptotic STAT1 axis. Further mechanistic evidence and investigation involving a larger patient cohort are needed to validate a radiation-induced, AF1q-driven tumor-suppressing effect, which may impact RC patient outcomes.
Authors
- Georg Oberhuber (ORCID: https://orcid.org/0000-0002-9701-821X)
- Elisabeth S. Gruber (ORCID: https://orcid.org/0000-0002-8646-1865)
- Dietmar Georg (ORCID: https://orcid.org/0000-0002-8327-3877)
- Joachim Widder (ORCID: https://orcid.org/0000-0002-9972-6690)
- Gerald Timelthaler (ORCID: https://orcid.org/0000-0002-0260-089X)
- Elisabeth Gurnhofer (ORCID: https://orcid.org/0000-0002-2082-3368)
- Robert Eferl (ORCID: https://orcid.org/0000-0002-6074-7144)
- Lukas Kenner (ORCID: https://orcid.org/0000-0003-2184-1338)
- Béla Teleky
- William Tse
Institutions
- University of Veterinary Medicine Vienna (AT)
- Comprehensive Cancer Center Vienna (AT)
- Christian Doppler Laboratory for Thermoelectricity (AT)
- Center For Biomarker Research In Medicine (AT)
- Case Western Reserve University (US)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/cam4.70658
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung
- Vienna Science and Technology Fund
- Österreichischen Akademie der Wissenschaften
- Austrian Science Fund
- Christian Doppler Forschungsgesellschaft
- Siemens Healthineers
- Bundesministerium für Bildung, Wissenschaft und Forschung
- HORIZON EUROPE Marie Sklodowska-Curie Actions