Sleep Deprivation‐Induced Anxiety Alleviated by Oral Administration of 4‐Aminopyridine in Male Mice

4-AP may be effective in reducing anxiety-like behavior in sleep-deprived mice by modifying the levels of NMDA-R, AMPA-R, and TNF-α, while simultaneously reducing oxidative stress induced by sleep deprivation in the hippocampus.

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Publication Details

Journal
Brain and Behavior
Published
2025-03-01
DOI
https://doi.org/10.1002/brb3.70382
Primary Topic
Olfactory and Sensory Function Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Sleep Deprivation‐Induced Anxiety Alleviated by Oral Administration of 4‐Aminopyridine in Male Mice

Ehsan Hosseini
Brain and Behavior
Olfactory and Sensory Function Studies
article

Sleep Deprivation‐Induced Anxiety Alleviated by Oral Administration of 4‐Aminopyridine in Male Mice

Ehsan Hosseini
article en

Abstract

4-AP may be effective in reducing anxiety-like behavior in sleep-deprived mice by modifying the levels of NMDA-R, AMPA-R, and TNF-α, while simultaneously reducing oxidative stress induced by sleep deprivation in the hippocampus.

Brain and BehaviorVol. 15(3)
Urmia University (IR)
Good health and well-being
Openalex Percentile: Top 95%
Olfactory and Sensory Function Studies
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Sleep Deprivation‐Induced Anxiety Alleviated by Oral Administration of 4‐Aminopyridine in Male Mice — Ehsan Hosseini · Brain and Behavior (2025) | TGRS Research Map | TGRS