A Spline‐Based Approach to Smoothly Constrain Hazard Ratios With a View to Apply Treatment Effect Waning
An alternative approach to modeling smooth treatment efficacy waning is demonstrated, enabling HR conditioning and marginal RMST calculation in a single framework, along with applications of the method beyond this use.
Authors
- Paul C. Lambert (ORCID: https://orcid.org/0000-0002-5337-663X)
- Mark J. Rutherford (ORCID: https://orcid.org/0000-0003-1557-6697)
- Angus Jennings (ORCID: https://orcid.org/0000-0002-4342-4108)
Institutions
- Norwegian Institute of Public Health (NO)
- University of Leicester (GB)
- Karolinska Institutet (SE)
- MRC Clinical Trials Unit at UCL (GB)
- Cancer Registry of Norway (NO)
- University College London (GB)
Publication Details
- Journal
- Statistics in Medicine
- Published
- 2025-03-09
- DOI
- https://doi.org/10.1002/sim.70035
- Primary Topic
- Advanced Causal Inference Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research