Using MALDI‐FTICR Mass Spectrometry to Enhance ZooMS Identifications of Pleistocene Bone Fragments Showing Variable Collagen Preservation
Our work highlights the robustness of traditional MALDI-TOF ZooMS for retrieving collagen and for providing taxonomic identifications with low failure rates, features that are critical when processing large numbers of samples. MALDI-FTICR shows better potential when working with precious samples or degraded collagen. This study advances the analytical detection of peptides by optimising the ZooMS workflow and by tailoring it to specific archaeological contexts showing variation in degree of preservation.
Authors
- Fabrice Bray (ORCID: https://orcid.org/0000-0002-4723-8206)
- Jean‐Jacques Hublin (ORCID: https://orcid.org/0000-0001-6283-8114)
- Foni Le Brun‐Ricalens
- Jean‐Christophe Castel (ORCID: https://orcid.org/0000-0002-2366-5596)
- Eugène Morin (ORCID: https://orcid.org/0000-0002-4840-0156)
- Christian Rolando
- Karen Ruebens (ORCID: https://orcid.org/0000-0002-5621-5786)
- Jean‐Guillaume Bordes
- Pauline Raymond
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Collège de France (FR)
- Université de Lille (FR)
- Université Paris Sciences et Lettres (FR)
- Natural History Museum of Geneva (CH)
- De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (FR)
- Trent University (CA)
- University of Reading (GB)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1002/rcm.10019
- Primary Topic
- Archaeology and ancient environmental studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- European Regional Development Fund