Age at Menarche and Coronary Artery Disease Risk: Divergent Associations With Different Sources of Variation
These results are consistent with earlier AAM causally increasing risk of CAD but suggest that later AAM itself does not cause increased risk of CAD; rather, sources of variation in AAM other than common genetic variants can cause both later AAM and increased risk of CAD. Dysglycemia, dyslipidemia, and central adiposity are candidate mediators of the association of later AAM with increased risk of CAD.
Authors
- Ambreen Sonawalla (ORCID: https://orcid.org/0000-0003-4342-5343)
- Daniel I. Chasman (ORCID: https://orcid.org/0000-0003-3357-0862)
- Yee-Ming Chan (ORCID: https://orcid.org/0000-0003-0554-8502)
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Boston Children's Museum (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-03-09
- DOI
- https://doi.org/10.1210/clinem/dgaf141
- Primary Topic
- Reproductive Physiology in Livestock
- Type
- article
- Field-Weighted Citation Impact
- 0.00