OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility
AIs are effective but often discontinued because of arthralgia. This study explores the role of OATP1B transporters in AI-related side effects and the potential usage of transporter biomarkers to predict and reduce the risk of arthralgia associated with AI treatment.
Authors
- Jennifer E. Vaughn (ORCID: https://orcid.org/0000-0003-3891-3270)
- Kevin M. Huang (ORCID: https://orcid.org/0000-0001-6561-3295)
- Eman Abd El-Mordy Elsayed Ahmed (ORCID: https://orcid.org/0000-0003-0973-2630)
- Thomas Drabison
- Xiaolin Cheng (ORCID: https://orcid.org/0000-0002-7396-3225)
- Christopher C. Coss (ORCID: https://orcid.org/0000-0002-8184-9190)
- Nicholas A. Young (ORCID: https://orcid.org/0000-0002-9323-9437)
- Alex Sparreboom (ORCID: https://orcid.org/0000-0003-2660-6644)
- Hanieh Taheri
- Samuel K. Kulp (ORCID: https://orcid.org/0009-0003-8737-2092)
- Kara N. Corps (ORCID: https://orcid.org/0000-0002-5584-6738)
- Shuiying Hu (ORCID: https://orcid.org/0000-0002-9806-7734)
- Maryam B. Lustberg (ORCID: https://orcid.org/0000-0001-8559-5645)
- Yang Li (ORCID: https://orcid.org/0000-0001-9055-2332)
- Yan Jin (ORCID: https://orcid.org/0000-0002-4124-3362)
- Yan Yang (ORCID: https://orcid.org/0000-0001-5608-5785)
- Junan Li (ORCID: https://orcid.org/0000-0003-0381-9356)
Institutions
- Yale Cancer Center (US)
- The Ohio State University Wexner Medical Center (US)
- Yale University (US)
- The Ohio State University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0475
- Citations
- 1
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.05