Exploring The Role of TOP2A in the Intersection of Pathogenic Mechanisms Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis Based on Bioinformatics
There is a certain correlation between RA and IPF at the genetic level, and the molecular mechanisms of their pathogenesis overlap, which might be the reason for the progression of RA. Among the candidate genes we identified, TOP2A may influence the occurrence and development of RA and IPF through the TGF-β/Smad signal pathway. This could be beneficial to the study of the pathogenesis and treatment of RA and IPF.
Authors
- Shuilin Chen (ORCID: https://orcid.org/0000-0003-3603-0300)
- Yanlong Zhong (ORCID: https://orcid.org/0009-0003-8599-471X)
- Xiangfei Huang
- Shuyi Shi (ORCID: https://orcid.org/0009-0001-2265-0114)
- Yulong Ouyang
- Guihao Zheng
- Xin Hong
- Bei Hu (ORCID: https://orcid.org/0000-0002-5802-1694)
- Weihua Li (ORCID: https://orcid.org/0000-0002-6801-0737)
- Mengji Lu (ORCID: https://orcid.org/0000-0003-4287-9941)
- Yue Zhang (ORCID: https://orcid.org/0009-0005-8105-7803)
- Guicai Sun (ORCID: https://orcid.org/0000-0002-1306-7592)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jir.s497734
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52