Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study

<b>Background/objectives:</b> Chronic stress is a pervasive issue affecting individuals worldwide, with profound implications for mental and physical well-being. Panax ginseng, a widely used herbal supplement renowned for its adaptogenic properties, is hypothesized to alleviate some stress effects. This study aims to evaluate the impact of hydroponically grown <i>Red Panax ginseng</i> root powder with a high level of rare ginsenosides supplementation on perceived stress levels, as well as on the emotional and cognitive abilities of moderately stressed participants. <b>Methods:</b> A randomized, double-blind, controlled study was conducted with 149 participants. They were randomly assigned to either the Ginseng supplementation group (N = 72; 200 mg/day, including 24 mg of ginsenosides) or the Placebo group (N = 77). The intervention lasted for 3 weeks. The perceived stress level was measured at baseline (D0) and at the end of the intervention (D21) using a validated scale (PSS) alongside assessments of emotional (BDI and PANAS) and cognitive abilities (CANTAB subtests). <b>Results:</b> Significantly larger decreases in the PSS and negative affect score (PANAS) were observed following intervention in the Ginseng group compared with the Placebo group. Compared to the Placebo group, participants in the Ginseng group showed faster response latencies during a spatial planning task (OTSC subtest). In addition, there was a marginally larger decrease in the BDI score in the Ginseng group. <b>Conclusions:</b> These results confirm the emotional and cognitive benefits of <i>Red Panax ginseng</i> in moderately stressed adults and pave the way for further exploration of its use as a promising approach to improving psychological well-being.