Metabolic characterizations of PFOS-induced disruptions in early embryonic development
PFOS exposure disrupts key metabolic pathways critical for embryogenesis, including lipid, amino acid, and nucleotide metabolism. Molecular docking and transcriptomic integration highlight enzyme targeting as a potential mechanism of PFOS-induced developmental toxicity. These findings provide novel insights into the molecular and metabolic disruptions caused by PFOS, with implications for understanding its developmental toxicity.
Authors
- Yingtong Jiang
- Minjian Chen (ORCID: https://orcid.org/0000-0002-5742-5080)
- Bo Xu (ORCID: https://orcid.org/0000-0003-4805-4043)
- Mengyuan Zhu (ORCID: https://orcid.org/0000-0003-4825-4168)
- Lei Huang (ORCID: https://orcid.org/0000-0003-2820-1915)
- Yuntian Xu
Institutions
- Ministry of Education (KR)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.118024
- Citations
- 3
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 2.58