Hospital-Based Registry Analysis of Staging Efficacy and Proposed Staging Subclassification for Stage I HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Substaging of AJCC8 stage I for HPV-associated OPSCC by cT2 and cN2b (7thedition TNM stage) provided significant hazard consistency. Adoption may improve prognostic risk stratification and inform guidance in treatment decision making. Further validation of this staging is warranted.
Authors
- Mitchell Machtay (ORCID: https://orcid.org/0000-0002-0423-1231)
- F. Jeffrey Lorenz (ORCID: https://orcid.org/0000-0001-5902-7054)
- Sean S. Mahase (ORCID: https://orcid.org/0000-0003-3488-6981)
- Pierre Lavertu (ORCID: https://orcid.org/0000-0002-1265-105X)
- Ming Yao (ORCID: https://orcid.org/0000-0003-2932-0019)
- Neerav Goyal (ORCID: https://orcid.org/0000-0001-7783-1097)
- Michael Kharouta (ORCID: https://orcid.org/0000-0002-9766-2056)
- Rod Rezaee (ORCID: https://orcid.org/0000-0002-2978-6153)
Institutions
- University Hospitals of Cleveland (US)
- Advocate Illinois Masonic Medical Center (US)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Oral Oncology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.oraloncology.2025.107251
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00