Bone marrow mesenchymal stem cells improve bone cancer pain by inhibiting p38MAPK phosphorylation and microglia activation
Intrathecal injection of BMSCs can temporarily inhibit mechanical and thermal hyperalgesia in BCP mice without affecting motor function. This effect may be related to the inhibition of p-p38 protein expression and the inhibition of microglia but not to p-ERK and p-JNK.
Authors
- Xiaotong Ding (ORCID: https://orcid.org/0000-0003-3388-903X)
- Li-Jun Fan (ORCID: https://orcid.org/0000-0001-5947-1171)
- Houming Kan (ORCID: https://orcid.org/0000-0001-5792-2901)
- Xiaodie Gui (ORCID: https://orcid.org/0009-0004-9809-8305)
- Wotu Tian (ORCID: https://orcid.org/0009-0003-7204-6489)
- Xuetai Chen (ORCID: https://orcid.org/0000-0003-1564-6392)
- Liping Chen (ORCID: https://orcid.org/0009-0003-7037-9300)
- Wen Shen
- huang jinzhao (ORCID: https://orcid.org/0009-0006-0578-749X)
Institutions
- Xuzhou Medical College (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Medical Products Administration (CN)
- Peking Union Medical College Hospital (CN)
- Soochow University (CN)
Publication Details
- Journal
- The Korean journal of pain
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3344/kjp.24374
- Citations
- 1
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81