The association between retinol binding protein 4 (RBP4) and peripheral neuropathy in type-II diabetic patients

Background: The most common microvascular consequence of diabetes is peripheral neuropathy (PN). It is a very common ailment that has a significant impact on patient quality of life. The purpose of this study was to look into the possible link between retinol binding protein 4 (RBP4) and PN in individuals with type 2 diabetes mellitus, as the relationship between the two is still unclear. Methodology: During August and December 2023, we enrolled 152 participants, who were matched for age and sex, in a case control study. There were 50 healthy controls, 50 diabetic patients without PN, and 52 diabetic patients with PN. ELISA was used to measure serum RBP4. Results: Diabetic individuals with PN had significantly greater serum levels of RBP4 than diabetic patients without PN (P ˂ 0.001). Increased age (r = 0.262, P ˂ 0.01), DM duration (r = 0.565, P ˂ 0.01), and BMI (r = 0.183, P ˂ 0.05) were all substantially linked with RBP4 levels. RBP4 levels exhibited a negative correlation with HDL and a positive correlation with total cholesterol, triglycerides, LDL, and VLDL. Conclusion: Elevated RBP4 levels is strongly and independently linked with PN in type 2 diabetic patients, and may play an important role in PN progression. Keywords: diabetes mellitus; peripheral neuropathy, retinol binding protein 4. Citation: Nafakhi IA, Abdalsada NH. The association between retinol binding protein 4 and peripheral neuropathy in type II diabetic patients. Anaesth. pain & intensive care 2024;28(6): 1091-1096; DOI: 10.35975/apic.v28i6.2621 Received: May 93, 2024; Reviewed: June 04, 2024; Accepted: September 26, 2024