The association of atherosclerosis with cortisol and alpha-enolase levels and lipid profile

Background & objective: Atherosclerosis is a chronic disease characterized by the gradual buildup of plaque inside the arteries. It is the most common form of arteriosclerosis, which refers to the thickening and hardening of arterial walls. In atherosclerosis, some arteries have been narrowed by atherosclerotic plaque. We investigated the association of atherosclerosis with cortisol and alpha-enolase levels and lipid profile. Methodology: This study focused on measuring alpha-enolase 1 (αENO1) in patients with atherosclerosis. sixty patients diagnosed with atherosclerosis (36 males and 24 females) participated in this study. Their ages ranged from (45 to 65 years). Samples were collected from the open-heart unit at Al-Sadr Teaching Hospital, Najaf Governorate, Iraq. Thirty healthy people (15 males, 15 females) were selected as a control group. Results: The study showed that patients with atherosclerosis suffer from a clear increase in the concentration of alpha-enolase 1 (αENO1) and a clear increase in the concentration of cortisol, as well as an increase in the lipid profile (total cholesterol, triglycerides, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL). Conclusions: On the other hand, the study revealed a significant decrease in the amounts of high-density lipoprotein (HDL) in patients compared to the control group. Therefore, the findings of this investigation suggest that individuals suffering from atherosclerosis might. Abbreviations: αENO1 - alpha enolase 1; HDL - high density lipoprotein; LDL - low density lipoprotein; (2-PG)-2-phospho-D-glycrate; NO - nitric oxide; TG - triglyceride; BMI - body mass index; PEP - phosphoenolpyruvate; ACTH - adrenocorticotropic hormone; ROS - reactive oxygen species. Keywords: atherosclerosis, αENO1, cortisol, endothelial, macrophages, plasminogen, plasmin, reactive oxygen species. Citation: Mohammed UJ, Ali BM. The association of atherosclerosis with cortisol and alpha-enolase levels and lipid profile. Anaesth. pain intensive care 2024;28(6):1097-1104; DOI: 10.35975/apic.v28i6.2609 Received: July 10, 2024; Reviewed: September 11, 2024; Accepted: September 11, 2024