Pathogenic germline variants in cancer predisposition genes in patients with multiple primary cancers in an Asian population and the role of extended panel genetic testing
Patients with MPC were more likely to harbour a PGV. Extended testing improved PGV detection rates, particularly for less well-known cancer predisposition genes.
Authors
- Samuel G.W. Ow (ORCID: https://orcid.org/0000-0002-2229-7971)
- Seng Wee Cheo (ORCID: https://orcid.org/0000-0003-2879-5346)
- Soo Chin Lee (ORCID: https://orcid.org/0000-0002-5835-6419)
- Cindy Ow (ORCID: https://orcid.org/0000-0002-8081-4682)
- Andrea Li Ann Wong (ORCID: https://orcid.org/0000-0002-5860-7847)
- Gloria Chan (ORCID: https://orcid.org/0000-0003-4328-9548)
- Siew Eng Lim (ORCID: https://orcid.org/0000-0002-5959-8743)
- Robert J. Walsh (ORCID: https://orcid.org/0000-0002-3894-4598)
- Joanna Kae Ling Wong (ORCID: https://orcid.org/0000-0001-5498-2212)
- Zhao Jun (ORCID: https://orcid.org/0000-0002-6691-2999)
- Yi Wan Lim (ORCID: https://orcid.org/0000-0003-4823-5151)
- J.S.J. Lim
- Pei Yi Ong
Institutions
- National University of Singapore (SG)
- National University Cancer Institute, Singapore (SG)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104495
- Citations
- 3
- Primary Topic
- Multiple and Secondary Primary Cancers
- Type
- article
- Field-Weighted Citation Impact
- 4.06