Patients with neck endocrine tumors have an increased incidence of malignant diseases

Introduction: Cancer patients are at higher risk of developing second primary cancer compared to the general population. Primary hyperparathyroidism is associated with a higher incidence of malignant disease. This research aims to investigate the incidence of malignant diseases in patients treated for parathyroid adenoma and papillary thyroid carcinoma in the University Hospital for Tumors cohort. Patients and Methods: Data about malignant diseases in patients treated for parathyroid adenoma and papillary thyroid cancer were collected from the Head and Neck Surgery Department (University Hospital for Tumors) database. Differences were tested using c2-test and the Mann-Whitney test. Results: Among 75 patients surgically treated for parathyroid adenoma, fourteen (18.6%) had a malignant disease. Among 90 patients surgically treated for papillary thyroid cancer, thirteen (14.4%) were treated for another malignant disease. The difference between groups was not statistically significant (p=0.465). Breast cancer was the most common malignant disease in both groups. Conclusion: Awareness of increased risk for malignancy in patients treated for neck endocrine tumors could lead to earlier detection of malignant diseases.