MRI-guided hypofractionated intensity-modulated radiation therapy after whole-breast simultaneous integrated boost radiation in early breast cancer: a non-surgical approach

Radical radiotherapy is a novel non-surgical approach to the treatment of early breast cancer. In order to administer a sufficient dose of radiation to the tumor while minimizing the side effects, the exposure to the surrounding normal tissues must be minimized. A 46-year-old woman with early-stage triple-negative breast cancer was treated curatively with MRI-guided hypofractionated intensity-modulated radiation therapy after a whole-breast integrated boost radiation, because the patient refused surgery and chemotherapy. Six months after treatment, the tumor disappeared completely without adjuvant chemotherapy, and there were no recurrences or adverse events two years after treatment. In conclusion, MRI-guided hypofractionated intensity-modulated radiation therapy following simultaneous whole-breast integrated boost radiotherapy may be a feasible alternative treatment for early breast cancer.