Lycorine Pre-Treatment Alleviates Microglia Inflammation After Cerebral Ischemia by Inhibiting NF-κB Phosphorylation
In summary, our research indicates that LYC pre-treatment has significant anti-inflammatory effects by attenuating inflammation levels through NF-κB inhibition, which contributes to potential therapeutic benefits in ischemic stroke (IS) and may improve disease prognosis. LYC may serve as an adjunctive clinical pre-treatment for IS, which has to be confirmed by clinical trials in the future.
Authors
- Vincent Kam Wai Wong (ORCID: https://orcid.org/0000-0002-2951-8108)
- Wuyan Zheng (ORCID: https://orcid.org/0000-0002-5133-9472)
- Betty Yuen Kwan Law (ORCID: https://orcid.org/0000-0002-8926-3960)
- Yuanyuan Zeng (ORCID: https://orcid.org/0000-0002-2260-4468)
- Yuhan Li (ORCID: https://orcid.org/0000-0002-7377-4889)
- Yuping Wang (ORCID: https://orcid.org/0000-0001-6419-1983)
- Wan-Yu Wu (ORCID: https://orcid.org/0000-0002-9183-673X)
- Bo Qin (ORCID: https://orcid.org/0000-0002-4283-4041)
Institutions
- Macau University of Science and Technology (MO)
- Southwest Medical University (CN)
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-03-09
- DOI
- https://doi.org/10.3390/brainsci15030290
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00