Neuroprotective Effects of Early TLR4 Blockade with Compound C34 in Temporal Lobe Epilepsy: Alleviation of Neuroinflammation and Apoptosis
These findings highlight the importance of early intervention in reducing neuronal death and suppressing neuroinflammation in an epilepsy model. Inhibiting TLR4 immediately after seizure induction may serve as a potential therapeutic strategy to minimize inflammation-mediated neuronal damage in TLE. Further research is needed to explore the long-term effects of TLR4 inhibition in epilepsy treatment.
Authors
- Nima Naderi (ORCID: https://orcid.org/0000-0003-4591-8918)
- Hamid Gholami Pourbadie (ORCID: https://orcid.org/0000-0002-7634-7428)
- Roya Varmazyar
- Rasoul Ghasemi (ORCID: https://orcid.org/0000-0002-1394-6853)
- Hanieh Javid
Institutions
- Pasteur Institute of Iran (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-03-08
- DOI
- https://doi.org/10.5812/ijpr-159165
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00