Lactylation-related molecular subtyping reveals the immune heterogeneity and clinical characteristics in ulcerative colitis
Using high-throughput transcriptomic data, we identified hub LRGs and highlighted the role of lactate-mediated lactylation in UC. MSN and MAPRE1 were confirmed to be upregulated in an inflammatory environment, underscoring their potential for personalized UC diagnosis and treatment.
Authors
- Runxi Fu (ORCID: https://orcid.org/0000-0001-6513-3152)
- Kankan Cao (ORCID: https://orcid.org/0000-0001-9242-1440)
- Shangjian Luo
- Yang Xie (ORCID: https://orcid.org/0000-0002-9421-301X)
- Yingwei Chen (ORCID: https://orcid.org/0000-0001-8429-252X)
- Xiaoman Liu (ORCID: https://orcid.org/0000-0002-2371-4570)
- Wensong Ge
- Jinyang Zhai
Institutions
- XinHua Hospital (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.bbrc.2025.151584
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China