Monitoring of microsurgically and endovascularly treated aneurysms (META): protocol for an international multicentre retrospective cohort study

Intracranial aneurysms (IAs) are abnormal outpouchings or dilations on the main blood vessels supplying the brain. 3% of the general population have IAs and the majority will remain asymptomatic however a proportion will go on to rupture and cause subarachnoid haemorrhage (SAH), which is a condition associated with a significant rate of death and disability. The treatment of both ruptured and unruptured IAs aims to prevent future aneurysm rupture leading to SAH. Historically, the only treatment modality for IAs was a neurosurgical operation called microsurgical clipping but more recently endovascular treatment, whereby the aneurysms can be treated using catheters inserted into the arteries of the groyne or wrist has become the predominant treatment. However, there are very few studies describing the long-term outcomes of microsurgical clipping or endovascular treatment, particularly with respect to the requirement for aneurysm re-treatment or SAH due to rupture of a previously treated aneurysm. The aim of this study is to assess the outcomes following microsurgical clipping and endovascular treatment of a large number of both ruptured and unruptured IA over an extended follow-up period, with a view to providing data that will permit us to optimise the follow-up of patients with IA following treatment.

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Publication Details

Journal
British Journal of Neurosurgery
Published
2025-03-09
DOI
https://doi.org/10.1080/02688697.2025.2471931
Primary Topic
Intracranial Aneurysms: Treatment and Complications
Type
article
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article

Monitoring of microsurgically and endovascularly treated aneurysms (META): protocol for an international multicentre retrospective cohort study

Cathal John Hannan, Ashraf Abouharb, Patrick Grover, Raghu Vindlacheruvu et al.
British Journal of Neurosurgery
Intracranial Aneurysms: Treatment and Complications
article

Monitoring of microsurgically and endovascularly treated aneurysms (META): protocol for an international multicentre retrospective cohort study

Cathal John Hannan, Ashraf Abouharb, Patrick Grover, Raghu Vindlacheruvu, Matthew Crockett, Daniel Walsh, Mahmoud Kamel, Jack Henry, Patrick Nicholson, Rikin Trivedi, Nitin Mukerji, Benjamin Franklin Fisher, Diederik Bulters, Samir Matloob, Howard L. Brydon, Mohsen Javadpour, Ian Anderson, Abdurrahman I. Islim, Mario Teo, Ahilan Kailaya-Vasan, Omar Kouli, James Galea, David Brennan, D. Sweeney, Ioannis Fouyais
article en

Abstract

Intracranial aneurysms (IAs) are abnormal outpouchings or dilations on the main blood vessels supplying the brain. 3% of the general population have IAs and the majority will remain asymptomatic however a proportion will go on to rupture and cause subarachnoid haemorrhage (SAH), which is a condition associated with a significant rate of death and disability. The treatment of both ruptured and unruptured IAs aims to prevent future aneurysm rupture leading to SAH. Historically, the only treatment modality for IAs was a neurosurgical operation called microsurgical clipping but more recently endovascular treatment, whereby the aneurysms can be treated using catheters inserted into the arteries of the groyne or wrist has become the predominant treatment. However, there are very few studies describing the long-term outcomes of microsurgical clipping or endovascular treatment, particularly with respect to the requirement for aneurysm re-treatment or SAH due to rupture of a previously treated aneurysm. The aim of this study is to assess the outcomes following microsurgical clipping and endovascular treatment of a large number of both ruptured and unruptured IA over an extended follow-up period, with a view to providing data that will permit us to optimise the follow-up of patients with IA following treatment.

British Journal of NeurosurgeryVol. 40(2)
Barking, Havering And Redbridge University Hospitals NHS Trust (GB), Cardiff and Vale University Health Board (GB), North Bristol NHS Trust (GB), University College London Hospitals NHS Foundation Trust (GB), University of Ulster (GB), Royal College of Surgeons in Ireland (IE), University of Liverpool (GB), Trinity College Dublin (IE), Leeds Teaching Hospitals NHS Trust (GB), Manchester Academic Health Science Centre (GB), Western General Hospital (GB), Royal Stoke University Hospital (GB), James Cook University Hospital (GB), Beaumont Hospital (IE), Botsford Hospital (US), Cork University Hospital (IE), Cambridge University Hospitals NHS Foundation Trust (GB), Princess Royal Hospital (GB), Walton Centre (GB), University Hospital Southampton NHS Foundation Trust (GB), University of Manchester (GB), South Tees Hospitals NHS Foundation Trust (GB), King's College Hospital NHS Foundation Trust (GB), Salford Royal Hospital (GB), Queen's Hospital (GB), Royal Victoria Hospital (GB), Beaumont Hospital, Dearborn (US), The Beaumont Hospital (GB), Oxford University Hospitals NHS Trust (GB), Addenbrooke's Hospital (GB), University College London (GB)
Openalex Percentile: Top 93%
Intracranial Aneurysms: Treatment and Complications
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