SRA deficiency induces follicular dysplasia by disrupting the hypothalamic Kisspeptin-GPR54 system in mice
SRA enhances ERα-mediated Kiss1 transcription in the AVPV nucleus to control the kisspeptin-GPR54 system in the hypothalamus, essential for regulating ovulation through the hypothalamus-pituitary-ovary axis.
Authors
- Xinzhe Wang
- Xinhui Kou (ORCID: https://orcid.org/0000-0002-7662-6689)
- Keshu Cai (ORCID: https://orcid.org/0000-0002-9543-3575)
- Yongning Zhai
- Yun Xue (ORCID: https://orcid.org/0009-0008-6552-1604)
- Jing Jin (ORCID: https://orcid.org/0009-0002-3774-6546)
- Huifang Zhou
- Yinyin Ding
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Nanjing Children's Hospital (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Biology of Reproduction
- Published
- 2025-03-09
- DOI
- https://doi.org/10.1093/biolre/ioaf049
- Citations
- 1
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 1.70