Preference, adherence, and acceptability of 3 nonmedicated intravaginal rings of differing external diameters: a randomized, crossover trial
Although the 46-mm ring was preferred by more women and had higher rates of adherence compared to the other 2 rings, the 56-mm ring was rated as equally acceptable with significantly fewer reports of expulsions/removals compared to the other 2 rings. These data confirm that the current 54 to 58 mm diameter of vaginal rings on the market and in development is acceptable and performs well. Future studies should explore the effect of other mechanical attributes, such as compressibility, on preference, adherence, and acceptability, as well as investigating ring characteristics in other populations.
Authors
- Barbara Friedland (ORCID: https://orcid.org/0000-0002-5041-3634)
- Jessica Atrio (ORCID: https://orcid.org/0000-0002-3505-643X)
- Sandeep Shetty (ORCID: https://orcid.org/0000-0002-7390-5228)
- Ruth Merkatz (ORCID: https://orcid.org/0000-0002-4646-2003)
- Ann Gottert (ORCID: https://orcid.org/0000-0001-6422-9478)
- Marlena Plagianos (ORCID: https://orcid.org/0000-0003-4718-5674)
- Nicole Roselli
- Renee Rolston
- Kilvia Maria Viana Ávila
- Lisa B. Haddad (ORCID: https://orcid.org/0000-0002-7631-6760)
- Carla Marinho (ORCID: https://orcid.org/0000-0003-2798-2828)
- Minh-Loi Nguyen (ORCID: https://orcid.org/0009-0003-2630-3325)
- Irene V Bruce
- Jessica M. Sales (ORCID: https://orcid.org/0000-0002-9734-0735)
- J. Brady Burnett-Zieman
Institutions
- Albert Einstein College of Medicine (US)
- NewYork–Presbyterian Hospital (US)
- Emory University (US)
- Cornell University (US)
- New York Hospital Queens (US)
- NYU Langone Health (US)
- Presbyterian Hospital (US)
- Bellevue Hospital Center (US)
- Population Council (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- American Journal of Obstetrics and Gynecology
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1016/j.ajog.2025.03.001
- Citations
- 1
- Primary Topic
- Reproductive Health and Contraception
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Emory University
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases