BMP9 alleviates iron accumulation-induced osteoporosis via the USP10/FOXO1/GPX4 axis
This study reveals that BMP9 inhibits ferroptosis through the USP10/FOXO1/GPX4 axis, providing a new therapeutic strategy for osteoporosis caused by iron accumulation.
Authors
- Dagang Tang
- Xiaoji Luo
- Runhan Zhao (ORCID: https://orcid.org/0000-0002-5681-7568)
- Ningdao Li (ORCID: https://orcid.org/0009-0000-6627-8476)
- Yanran Huang (ORCID: https://orcid.org/0000-0001-8064-4006)
- Yulong Duan (ORCID: https://orcid.org/0000-0002-8431-6197)
- Xiao Qu
- Jun Zhang (ORCID: https://orcid.org/0000-0002-4479-694X)
- Xie Zhou (ORCID: https://orcid.org/0009-0001-1743-0010)
- Yafei Zhu
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical and Pharmaceutical College (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-09
- DOI
- https://doi.org/10.1016/j.jare.2025.03.012
- Citations
- 8
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 6.45