Neutrophil extracellular traps-triggered hepatocellular senescence exacerbates lipotoxicity in non-alcoholic steatohepatitis
Our findings elucidate a novel mechanism by which neutrophil-derived Notch driven NETs exacerbate NASH by promoting cell senescence, thereby contributing to hepatic steatosis and fibrosis. This insight may provide potential intervention strategies and therapeutic targets for NASH treatment.
Authors
- Zhiqiang Fang (ORCID: https://orcid.org/0000-0002-0844-7507)
- Yu‐Wei Ling
- Ming Xu (ORCID: https://orcid.org/0000-0001-8846-2880)
- Hao Xu (ORCID: https://orcid.org/0000-0002-2169-115X)
- Lin Wang (ORCID: https://orcid.org/0000-0001-5586-3012)
- Jingjing Liu (ORCID: https://orcid.org/0000-0002-3266-7331)
- Fei He (ORCID: https://orcid.org/0000-0001-8368-5030)
- Zhen‐Sheng Yue
- Ping Song (ORCID: https://orcid.org/0000-0002-3473-8025)
- Juanli Duan
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-09
- DOI
- https://doi.org/10.1016/j.jare.2025.03.015
- Citations
- 18
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 14.35
Funders
- National Natural Science Foundation of China
- Key Technologies Research and Development Program
- National Key Research and Development Program of China