The Effect of Manilkara Zapota L on The Histopathological Gastric Induced by Absolute Ethanol

Background: Gastric ulcers are a significant health issue caused by various factors, including excessive alcohol consumption. Manilkara zapota (M. zapota) has been reported to exhibit anti-inflammatory and antioxidant properties, which may contribute to its gastroprotective effects. Objective: This study aimed to evaluate the differences in the number of ulcers, ulcer depth, lesion area, and inflammatory cell density in the stomachs of Wistar rats induced by absolute ethanol and treated with M. Methods: This experimental study used a post-test-only control group design with Wistar rats as subjects. Results: Gastric ulcer lesions were observed with varying depths and inflammatory cell densities. The Kruskal-Wallis test showed a significant difference in the median number of ulcer lesions among the treatment groups (p = 0.0182). Post-hoc analysis confirmed significant variations between groups. Conclusion: M. zapota fruit extract demonstrated protective effects against ethanol-induced gastric injury, reducing ulcer number, depth, lesion area, and inflammatory cell density. Its gastroprotective efficacy was comparable to C. burmanni, indicating its potential as a natural therapeutic agent for gastric protection. Further research is needed to elucidate the underlying mechanisms and clinical applications.