Beyond the gut: Systemic levels of short-chain fatty acids are altered in patients with heart failure
In patients with HF, serum levels of acetate and propionate are lower across the HF spectrum, whereas serum butyrate levels are elevated in HFrEF, but lower in HFmrEF/HFpEF. These alterations in SCFA profiles suggest a microbiome-driven metabolic dysregulation, which appears to differ between HF subtypes.
Authors
- Ido P. Kema (ORCID: https://orcid.org/0000-0003-1166-6169)
- Rudolf A. de Boer (ORCID: https://orcid.org/0000-0002-4775-9140)
- Christian Ley
- Stephan J. L. Bakker (ORCID: https://orcid.org/0000-0003-3356-6791)
- B. Daan Westenbrink (ORCID: https://orcid.org/0000-0002-1362-7019)
- Barbara M. Bakker (ORCID: https://orcid.org/0000-0001-6274-3633)
- Michiel Rienstra (ORCID: https://orcid.org/0000-0002-2581-070X)
- Michel J. Vos (ORCID: https://orcid.org/0000-0001-9379-2219)
- Dirk Jan van Veldhuisen (ORCID: https://orcid.org/0000-0003-1611-7935)
- Wouter C. Meijers (ORCID: https://orcid.org/0000-0002-3287-6766)
- Thomas M. Gorter (ORCID: https://orcid.org/0000-0001-5000-8359)
- Constantin L. Palm (ORCID: https://orcid.org/0009-0006-6044-1299)
- Stéphane De Wit
Institutions
- Carl von Ossietzky Universität Oldenburg (DE)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Erasmus MC Cancer Institute (NL)
Publication Details
- Journal
- International Journal of Cardiology
- Published
- 2025-03-09
- DOI
- https://doi.org/10.1016/j.ijcard.2025.133124
- Citations
- 4
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 4.66