Innate immune system signaling and intestinal dendritic cells migration to the brain underlie behavioral changes after microbial colonization in adult mice
Changes in neural plasticity occur rapidly upon initial gut microbial colonization and involve innate immune signaling to the brain, mediated by CD11b<sup>+</sup>CD11c<sup>+</sup>CD103<sup>+</sup> dendritic cell migration. The results identify a new target with therapeutic potential for DGBIs developing in context of increased gut and blood-brain barrier permeability.
Authors
- Giada De Palma (ORCID: https://orcid.org/0000-0002-2063-7741)
- Přemysl Berčík (ORCID: https://orcid.org/0000-0001-8707-1781)
- Andrew J. Macpherson (ORCID: https://orcid.org/0000-0002-7192-0184)
- Narjis Kraïmi (ORCID: https://orcid.org/0000-0002-1872-4715)
- Michael G. Surette (ORCID: https://orcid.org/0000-0003-0086-4995)
- Fernando G. Chirdo (ORCID: https://orcid.org/0000-0002-7099-9142)
- Kathy D. McCoy (ORCID: https://orcid.org/0000-0002-3900-9227)
- Vivek M. Philip (ORCID: https://orcid.org/0000-0001-5126-707X)
- Chiko Shimbori (ORCID: https://orcid.org/0000-0003-4057-5688)
- Siegfried Hapfelmeier (ORCID: https://orcid.org/0000-0002-6913-7932)
- Elena F. Verdú (ORCID: https://orcid.org/0000-0001-6346-2665)
- Olivier P. Schären
- Stephen M. Collins (ORCID: https://orcid.org/0000-0003-1613-3732)
- Hailong Zhang (ORCID: https://orcid.org/0000-0002-4903-010X)
- Fang Liu (ORCID: https://orcid.org/0000-0002-4568-3859)
- Jun Lü (ORCID: https://orcid.org/0000-0003-2221-1872)
Institutions
- University of Bern (CH)
- Centre for Addiction and Mental Health (CA)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- University of Calgary (CA)
- University Hospital of Bern (CH)
- Population Health Research Institute (CA)
- Instituto de Física La Plata (AR)
- Institut de Recherche en Santé Digestive (FR)
- McMaster University (CA)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-03-09
- DOI
- https://doi.org/10.1016/j.bbi.2025.03.012
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05