T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma
RAS(ON) multi-selective inhibitors enhance antitumor immunity in preclinical models of PDAC, resulting in deeper and more durable responses when combined with immunotherapy. These findings support the clinical evaluation of immune-based strategies that may prolong the response to RAS inhibitor therapies as well as overcome issues of therapeutic resistance to inhibitors alone. See related commentary by Lasse Opsahl and Pasca di Magliano, p. 1537.
Authors
- Marie Ménard (ORCID: https://orcid.org/0000-0003-1511-4361)
- Adam B. Kramer (ORCID: https://orcid.org/0000-0001-7818-3837)
- William P. Vostrejs (ORCID: https://orcid.org/0000-0002-1659-0186)
- Elsa Quintana (ORCID: https://orcid.org/0000-0002-4123-1695)
- Robert H. Vonderheide (ORCID: https://orcid.org/0000-0002-7252-954X)
- Nataliya Tovbis Shifrin (ORCID: https://orcid.org/0000-0002-4312-0606)
- Ben Z. Stanger (ORCID: https://orcid.org/0000-0003-0410-4037)
- Mallika Singh (ORCID: https://orcid.org/0009-0003-0234-1589)
- Samantha B. Kemp (ORCID: https://orcid.org/0000-0002-1505-4015)
- Margo Orlen (ORCID: https://orcid.org/0000-0002-9834-6282)
- Nune Markosyan (ORCID: https://orcid.org/0000-0003-4618-9454)
- Jayne C. McDevitt (ORCID: https://orcid.org/0000-0001-5261-394X)
- Il‐Kyu Kim (ORCID: https://orcid.org/0000-0002-4661-0133)
- Rina Sor (ORCID: https://orcid.org/0000-0003-2042-5746)
- Cynthia Clendenin (ORCID: https://orcid.org/0000-0003-4535-2088)
Institutions
- Revolution Medicines (United States) (US)
- UPMC Hillman Cancer Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1475
- Citations
- 26
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 27.18