Design, Synthesis, Anticonvulsant Evaluation, and Molecular Docking Studies of New GABA<sub>A</sub> Agonist Derivatives
The synthesized molecules exhibited moderate to good activity compared to the control group. Derivative 3c notably increased seizure latency relative to the control. Flumazenil inhibitory effect tests indicated that 3c protects against PTZ-induced seizures via the synaptic GABA<sub>A</sub> receptor.
Authors
- Parsa Moghimi-Rad
- Massoud Amanlou (ORCID: https://orcid.org/0000-0002-8559-1668)
- Mansur Nassiri Koopaei
- Mohammad Sharifzadeh (ORCID: https://orcid.org/0000-0003-2991-7384)
- Ebrahim Saeedian Moghadam (ORCID: https://orcid.org/0000-0003-1206-2703)
- Nasrin Nassiri Koopaei
- Tahmineh Akbarzadeh
- Mohsen Amini
Institutions
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-03-02
- DOI
- https://doi.org/10.5812/ijpr-157392
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91