Cutaneous Adverse Events Following COVID-19 Vaccination in Japan: A Questionnaire Survey
We conducted a nationwide survey in Japan to clarify the clinical spectrum of these events. An initial questionnaire was sent to 126 dermatology facilities, and responses were obtained from 66 (52.4%). Among these responding facilities, the most commonly identified cutaneous adverse events after COVID-19 vaccination were urticaria (49 (74.2%)), delayed local reactions (37 (56.1%)), erythema multiforme (31 (47.0%)), and alopecia (30 (45.5%)). In the detailed survey, the primary adverse events were EM (19 (20.9%)), bullous pemphigoid (7 (7.7%)), and alopecia (6 (6.6%)). The mean latency from vaccination to onset was 13.1 days, and the mean duration of symptoms was 74.2 days. Although this study cannot establish a direct causal relationship between vaccination and adverse events, it highlights the need for dermatologists to recognize potential cutaneous reactions and provide appropriate care.
Authors
- Chisa Nakashima (ORCID: https://orcid.org/0000-0002-9653-6824)
- S. Imafuku
- Akihiko Yuki (ORCID: https://orcid.org/0000-0002-6271-3984)
- Saeko Nakajima (ORCID: https://orcid.org/0000-0003-0831-1447)
- Yumiko Kubota (ORCID: https://orcid.org/0009-0008-4465-4176)
- Yoko Fuyuno (ORCID: https://orcid.org/0000-0002-6209-7923)
- Susumu Fujiwara (ORCID: https://orcid.org/0000-0002-5220-713X)
- Yayoi Tada (ORCID: https://orcid.org/0000-0003-3743-135X)
- Chiaki Takahashi (ORCID: https://orcid.org/0000-0003-3390-9563)
- Hisao Kawahira (ORCID: https://orcid.org/0000-0001-5288-8089)
- Nana Kagawa
- Takeshi Nakahara (ORCID: https://orcid.org/0000-0003-2811-8273)
- Kotaro Hayashi (ORCID: https://orcid.org/0000-0002-0134-2913)
- Atsushi Otsuka (ORCID: https://orcid.org/0000-0001-6472-0988)
- Akihisa Yamamoto (ORCID: https://orcid.org/0000-0002-3394-2147)
- Yumi Aoyama (ORCID: https://orcid.org/0000-0003-3701-5575)
- Hayato Takahashi (ORCID: https://orcid.org/0000-0001-6768-8821)
- Riichiro Abe (ORCID: https://orcid.org/0000-0002-7582-8609)
- Masahito Yasuda (ORCID: https://orcid.org/0000-0002-2907-640X)
- Daisuke Tsuruta (ORCID: https://orcid.org/0000-0001-6283-0251)
- Ayaki Matsumoto
- Emi Sato (ORCID: https://orcid.org/0000-0001-9394-653X)
- Risa Matsuo (ORCID: https://orcid.org/0000-0002-1486-5369)
- Daisuke Watanabe (ORCID: https://orcid.org/0000-0002-3658-5704)
- Y Yamamura
- Norito Katoh
Institutions
- Kagoshima University (JP)
- Kyushu University (JP)
- Asahikawa Medical University (JP)
- Aichi Medical University (JP)
- Gunma University (JP)
- Kyoto Prefectural University (JP)
- Kawasaki Medical School (JP)
- Keio University (JP)
- Kyoto University (JP)
- Fukuoka University (JP)
- Kyoto Prefectural University of Medicine (JP)
- Fukuoka Hospital (JP)
- Kyushu University Hospital (JP)
- Kagoshima University Hospital (JP)
- North Medical Center (JP)
- Takarazuka City Hospital (JP)
- Fukuoka City Hospital (JP)
- Kobe University (JP)
- Niigata University (JP)
- Teikyo University (JP)
- Kindai University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-03-08
- DOI
- https://doi.org/10.7759/cureus.80257
- Primary Topic
- Dermatological and COVID-19 studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00