Late-onset bone granulomatous reaction of hand from immune checkpoint-inhibitors detected on FDG-PET/CT
Immune checkpoint inhibitors (ICIs) enhance antitumor immunity by inhibiting intrinsic immune-suppressive pathways. Although immune-related adverse events (irAEs) typically arise in the early phase of ICI therapy, delayed manifestations have been reported, even months to years following treatment discontinuation. We report a case of a late-onset bone granulomatous reaction in the hand of a male patient in his seventies with a history of ICI therapy, identified on FDG-PET/CT, 4 years after discontinuation of ICI therapy. This case indicates the importance of recognizing the possibility of delayed irAEs, even in patients who have undergone long-term discontinuation of immunotherapy.
Authors
- Miki Nishimori (ORCID: https://orcid.org/0009-0008-8165-0780)
- Tomoaki Yamanishi (ORCID: https://orcid.org/0000-0003-0890-9529)
- Takayasu Izumi
- Noriko Nitta
- Kouki Togami
- Tomohiro Matsumoto (ORCID: https://orcid.org/0000-0002-2375-4919)
- Kazufumi Takamatsu (ORCID: https://orcid.org/0000-0002-0453-1242)
- Hitomi Iwasa (ORCID: https://orcid.org/0000-0001-9626-7866)
- Kenta Ogi
- Shudai Muramatsu (ORCID: https://orcid.org/0000-0001-5613-8664)
- Mayuko Yamamoto
- Rika Yoshimatsu (ORCID: https://orcid.org/0009-0004-6273-0022)
- Takuji Yamagami (ORCID: https://orcid.org/0000-0002-2375-5321)
- Kosuke Nakaji
- Kana Miyatake
Institutions
- Kochi Medical School Hospital (JP)
- Kōchi University (JP)
Publication Details
- Journal
- Radiology Case Reports
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1016/j.radcr.2025.02.054
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05