Profiling type I and II interferon responses reveals distinct subgroups of pediatric patients with autoinflammatory disorders
Both IFN-α2 quantification and NanoString reliably distinguish type I interferonopathies from other diseases. Type I and II interferons induce different transcriptomic signatures <i>in vitro</i> and <i>in vivo,</i> and our results highlight the value of monitoring both IFN-I and IFN-II in interferon-related diseases.
Authors
- Sarah Benezech (ORCID: https://orcid.org/0000-0002-9587-3896)
- Anaïs Nombel (ORCID: https://orcid.org/0009-0007-8564-9034)
- Marine Villard (ORCID: https://orcid.org/0000-0002-3905-8993)
- Sophie Trouillet‐Assant (ORCID: https://orcid.org/0000-0001-6439-4705)
- Rémi Pescarmona (ORCID: https://orcid.org/0000-0002-7218-3294)
- Samira Khaldi-Plassart
- Christine Lombard
- Alexandre Bélot (ORCID: https://orcid.org/0000-0003-4902-5332)
- Thierry Walzer (ORCID: https://orcid.org/0000-0002-0857-8179)
- Sébastien Viel (ORCID: https://orcid.org/0000-0002-5085-443X)
- Magali Perret (ORCID: https://orcid.org/0000-0002-9215-5186)
- Lorna Garnier
- Anne‐Perrine Foray (ORCID: https://orcid.org/0000-0002-7718-8473)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Hôpital Femme Mère Enfant (FR)
- Institut d’Hématologie et d’Oncologie Pédiatrique (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Lyon Sud (FR)
- bioMérieux (France) (FR)
- ERN GUARD-Heart (NL)
- Centre International de Recherche en Infectiologie (FR)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1016/j.jacig.2025.100450
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Hospices Civils de Lyon