Paracoccidioidomycosis as a Manifestation of Immune Reconstitution Inflammatory Syndrome in an HIV Patient: An Uncommon Presentation
A 50-year-old HIV-positive woman, nonadherent to antiretroviral therapy, developed asthenia, weight loss, and lymphadenopathy after restarting treatment. Imaging revealed adenopathies and a breast nodule, with biopsies confirming <i>Paracoccidioides brasiliensis</i>. Despite initial therapy failure (trimethoprim-sulfamethoxazole), liposomal amphotericin, corticosteroids, and a regimen change led to partial improvement until a psoas abscess required drainage, ultimately stabilizing her condition.
Authors
- Sérgio Augusto Lopes de Souza (ORCID: https://orcid.org/0000-0002-7901-4805)
- Isabel Cristina Melo Mendes (ORCID: https://orcid.org/0000-0002-3654-8436)
- Ana Helena Pereira Correia Carneiro (ORCID: https://orcid.org/0000-0001-9823-0071)
- Marilene Monteiro Paschoal (ORCID: https://orcid.org/0000-0002-8483-4242)
- Antônio Esmerahdson de Pinho da Silva
- Maria Célia Djahjah (ORCID: https://orcid.org/0000-0002-8798-9856)
- Luis Antonio Alves Lima
- Francine Cordeiro Lóta
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Hospital Universitário Clementino Fraga Filho (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1093/ofid/ofaf141
- Citations
- 1
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35