SRSF9 mediates oncogenic RNA splicing of SLC37A4 via liquid–liquid phase separation to promote oral cancer progression
This study elucidates the mechanism by which SRSF9 phase separation mediates splicing in oral cancer, thereby establishing a basis for considering SRSF9 and its associated SLC37A4-S isoforms as potential therapeutic targets for oral cancer treatment.
Authors
- Jinguan Lin
- Yaqian Han (ORCID: https://orcid.org/0000-0002-6716-4320)
- Yujuan Zhou
- Wu Zhu (ORCID: https://orcid.org/0000-0002-3645-7059)
- Yanyan Tang
- Hao Tian (ORCID: https://orcid.org/0000-0003-2005-4623)
- Longzheng Xia
- Lujuan Wang
- Qianjin Liao (ORCID: https://orcid.org/0000-0001-9320-3090)
- Ying Long (ORCID: https://orcid.org/0000-0003-0559-3012)
- Xuemeng Xu (ORCID: https://orcid.org/0000-0002-6093-7183)
- Wenjuan Yang (ORCID: https://orcid.org/0000-0001-7270-8356)
- Zongyao Ren (ORCID: https://orcid.org/0009-0004-6054-2052)
- Linda Oyang
- Xia Luo
- Peng Qiu (ORCID: https://orcid.org/0000-0002-2509-3683)
- Nayiyuan Wu (ORCID: https://orcid.org/0000-0001-5242-3206)
- Mingjing Peng
- Shiming Tan
- Xianjie Jiang
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Hunan Cancer Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1016/j.jare.2025.03.013
- Citations
- 9
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 7.25